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A kinetic hairpin transfer model for parvoviral DNA replication
K C Chen1, J J Tyson, M Lederman
1Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Journal of Molecular Biology
|July 20, 1989
Abstract:
The DNAs encapsidated by parvoviruses show distinctly different patterns with respect to the ratio of plus-to-minus strands and sequence heterogeneity at the ends. A kinetic model, based on differential rates of hairpin transfer at 3' termini, is described and shown to account for all known parvoviral DNA distributions.