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FCGR, Cetuximab, and Colorectal Cancer Survival-Letter

Francesca V Negri1, Daniela Boggiani1, Anita Rimanti1

  • 1Medical Oncology Unit, University Hospital of Parma, Parma, Italy.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 5, 2016
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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