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Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J

Sandhya R Pulivarthy1, Mattia Lion1, Guray Kuzu2

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; Department of Genetics, Harvard Medical School, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|October 5, 2016
PubMed
Summary

Nucleosome positioning at antigen receptor loci is cell type-specific, regulating gene accessibility for V(D)J recombination. This chromatin organization controls access for the recombination activating gene (RAG) recombinase during development.

Keywords:
V(D)J recombinationchromatinepigeneticslymphocytesnucleosome positioning

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