Related Experiment Video

Updated: Mar 14, 2026

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.4K

Role of Yes-associated protein in cancer: An update

Ramazan Abylkassov1, Yingqiu Xie1

  • 1Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.

Oncology Letters
|October 5, 2016
PubMed

Insights

Yes-associated protein (YAP), a key regulator in cell division, becomes active and moves to the nucleus. This review details YAP

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Yes-associated protein (YAP) is a critical cytoplasmic oncoprotein.
  • YAP is a downstream effector of the Hippo signaling pathway, crucial for cell proliferation and regeneration.
  • Strict regulation of YAP is essential due to its role in cellular processes.

Purpose of the Study:

  • To review the canonical pathways regulating Yes-associated protein (YAP).
  • To present recent findings on YAP regulation and its role in tumorigenesis.
  • To specifically examine YAP's involvement in prostate tumor progression.

Main Methods:

  • Literature review of canonical YAP pathways.
  • Analysis of recent research on YAP regulation.
  • Focus on YAP's role in prostate cancer development.

Main Results:

  • YAP's translocation from cytoplasm to nucleus upon activation.
  • YAP's role in transcribing genes for cell division and apoptosis.
  • YAP's intricate regulation by multiple systems.

Conclusions:

  • YAP is a strictly regulated protein with a significant role in cell cycle control.
  • Dysregulation of YAP is implicated in tumorigenesis, particularly prostate cancer.
  • Further understanding of YAP pathways is crucial for cancer research.
Keywords:
YAPcancerprostate cancer

More Related Videos

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs10:32

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

11.7K
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

7.5K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

4.2K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K