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Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
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Lessons from treatment resistant hyperlipidaemia.

Elizabeth Parsons1, Pankaj Gupta1, Prashanth Patel1

  • 1University Hospitals of Leicester NHS Trust, Department of Chemical Pathology and Metabolic Medicine , Level 4, Sandringham Building , Leicester Royal Infirmary , UK.

Oxford Medical Case Reports
|October 5, 2016
PubMed
Summary
This summary is machine-generated.

A woman with resistant hyperlipidaemia was diagnosed with amyloidosis and nephrotic syndrome. Treatment stabilized her kidney function and resolved the hyperlipidaemia, highlighting secondary causes.

Keywords:
hyperlipidaemialipidnephrotic syndromeproteinuria

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Area of Science:

  • Nephrology
  • Oncology
  • Endocrinology

Background:

  • Hyperlipidaemia is often associated with nephrotic syndrome.
  • However, oedema or proteinuria typically present before hyperlipidaemia.
  • This case presents a rare initial manifestation of nephrotic syndrome.

Observation:

  • A 68-year-old woman presented with sudden deterioration of hyperlipidaemia.
  • Investigations revealed nephrotic-range proteinuria, leading to a diagnosis of amyloidosis via renal biopsy.
  • The patient had previously well-controlled primary hyperlipidaemia.

Findings:

  • Chemotherapy stabilized renal function and reduced proteinuria.
  • Serum paraprotein was eliminated.
  • Resistant hyperlipidaemia resolved after treatment for amyloidosis.

Implications:

  • This case highlights the importance of investigating secondary causes of hyperlipidaemia.
  • Resistant hyperlipidaemia can be an early sign of underlying conditions like amyloidosis.
  • Early diagnosis and treatment of secondary hyperlipidaemia are crucial for patient outcomes.