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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

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Related Experiment Video

Updated: Mar 14, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Optical coherence tomography endoscopic probe based on a tilted MEMS mirror.

Can Duan1, Quentin Tanguy2, Antonio Pozzi3

  • 1Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL, 32611, USA; cduan@ufl.edu.

Biomedical Optics Express
|October 5, 2016
PubMed
Summary

A novel microendoscopic optical coherence tomography (OCT) probe, measuring only 2.7 mm, utilizes a tilted MEMS mirror on a silicon optical bench for compact, high-resolution imaging. This technology enables detailed 2D and 3D OCT imaging in various biological samples.

Keywords:
(110.4500) Optical coherence tomography(170.2150) Endoscopic imaging(170.3880) Medical and biological imaging(230.4685) Optical microelectromechanical devices

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Area of Science:

  • Biomedical Engineering
  • Optical Engineering
  • Medical Imaging

Background:

  • Minimally invasive endoscopic procedures require miniaturized imaging tools.
  • Optical coherence tomography (OCT) offers high-resolution cross-sectional imaging.
  • Existing endoscopic OCT probes often face limitations in size and assembly complexity.

Purpose of the Study:

  • To develop a compact microendoscopic OCT probe with a 2.7 mm outer diameter.
  • To demonstrate a novel integration of a 2-axis scanning MEMS mirror on a silicon optical bench (SiOB).
  • To achieve high-resolution 2D and 3D OCT imaging with the developed probe.

Main Methods:

  • Design and fabrication of a microendoscopic OCT probe incorporating a 45° tilted MEMS mirror on a SiOB.
  • Utilizing bimorph flexures and electrothermal actuators for MEMS mirror actuation.
  • Integration of GRIN lens and optical fiber with automatic alignment features.
  • Testing the probe with a time-domain OCT (TDOCT) system.

Main Results:

  • A 2.7 mm diameter microendoscopic OCT probe was successfully developed.
  • The probe achieved 2-axis side-view optical scanning with a 40° scan range at 5.5 Vdc.
  • A lateral scan area of 2.2 mm × 2.2 mm was achieved at a 3 mm working distance.
  • High-resolution 2D and 3D OCT images were acquired from various targets, including ex vivo and in vivo biological tissues.

Conclusions:

  • The novel SiOB-integrated tilted MEMS mirror enables a significantly reduced probe size and simplified assembly.
  • The developed microendoscopic OCT probe provides high-resolution imaging capabilities for diverse applications.
  • This technology holds promise for advancing minimally invasive diagnostic and surgical procedures.