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Related Experiment Video

Updated: Mar 14, 2026

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels
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Bundled-optode implementation for 3D imaging in functional near-infrared spectroscopy.

Hoang-Dung Nguyen1, Keum-Shik Hong2

  • 1Department of Cogno-Mechatronics Engineering, Pusan National University, 2 Busandaehak-ro, Geumjeong-gu, Busan 46241, South Korea.

Biomedical Optics Express
|October 5, 2016
PubMed
Summary

This study introduces a novel functional near-infrared spectroscopy (fNIRS) method using bundled optodes to detect brain hemodynamic changes. The technique enhances spatial resolution for brain activity imaging.

Keywords:
(100.2960) Image analysis(110.0110) Imaging systems(170.2655) Functional monitoring and imaging(300.0300) Spectroscopy

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique.
  • Accurate measurement of hemodynamic responses (oxy-hemoglobin and deoxy-hemoglobin) is crucial for understanding brain activity.
  • Existing fNIRS methods face limitations in spatial resolution for detailed brain imaging.

Purpose of the Study:

  • To develop and validate a novel bundled-optode fNIRS method for improved detection of hemodynamic changes.
  • To enhance the spatial resolution of 3D fNIRS imaging.
  • To assess brain-hemodynamic responses to cognitive tasks using the proposed method.

Main Methods:

  • Utilized fNIRS with 32 optodes to measure brain activity in five healthy male subjects during arithmetic tasks.
  • Computed 256 voxel coordinates in a 3D volume based on probe geometry.
  • Estimated mean path length factor using the Beer-Lambert equation to calculate absorption coefficients.
  • Constructed 3D fNIRS images using calculated oxy-hemoglobin and deoxy-hemoglobin concentrations.

Main Results:

  • The proposed bundled-optode fNIRS method demonstrated higher spatial resolution compared to conventional approaches.
  • Successfully detected brain-hemodynamic responses to arithmetic tasks.
  • Generated 3D fNIRS images with improved detail.

Conclusions:

  • The novel bundled-optode fNIRS method offers superior spatial resolution for brain activity detection.
  • This technique provides a more detailed understanding of brain hemodynamics.
  • The method is extendable for real-time 3D fNIRS imaging applications.