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Updated: Mar 14, 2026
Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
Published on: June 6, 2015
Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system
Iliya Sigal1, Margaret M Koletar2, Dene Ringuette3
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, 10 King's College Road, Toronto, ON M5S 3G4, Canada.
Abstract:
We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 μm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy.
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