Data of methylome and transcriptome derived from human dilated cardiomyopathy

Area of Science:

• Genomics
• Molecular Biology
• Cardiovascular Science

Background:

• DNA methylation and gene expression alterations are linked to human dilated cardiomyopathy (DCM).
• The left ventricle (LV) is pathologically affected in DCM, while the right ventricle (RV) serves as a normal control.
• Understanding these molecular changes is crucial for DCM research.

Purpose of the Study:

• To identify differentially methylated probes (DMPs) and differentially expressed genes (DEGs) between the LV and RV in human DCM.
• To investigate alterations in DNA methylation within the regulatory regions of genes critical for left ventricle development.

Main Methods:

• Comparative analysis of DNA methylation patterns (methylome analysis) between pathological LV and control RV tissues.
• Gene expression profiling to identify differentially expressed genes (DEGs).
• Bioinformatics analysis to pinpoint DMPs and DEGs associated with DCM.

Main Results:

• Significant differences in DNA methylation were observed between the LV and RV.
• Specific genes showed altered expression levels correlating with methylation changes in the LV.
• Alterations were particularly noted in regulatory regions of genes involved in left ventricle development.

Conclusions:

• Epigenetic modifications, specifically DNA methylation changes, play a role in the pathogenesis of human dilated cardiomyopathy.
• These findings highlight potential molecular targets for understanding and treating DCM.
• The study provides valuable data for further research into the genetic and epigenetic underpinnings of DCM.