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Updated: Mar 14, 2026
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
Morbility, clinical data and proteomic analysis of IUGR and AGA newborns at different gestational ages
M D Ruiz-González1, M D Cañete2, J L Gómez-Chaparro3
1Neonatology Unit, Pediatrics Service, Reina Sofía University Hospital, Andalusian Health Service, Menéndez Pidal Avenue, 14004 Córdoba, Spain.
Insights
This study analyzed serum proteomic differences in newborns with intrauterine growth retardation (IUGR) compared to appropriate for gestational age (AGA) infants. Findings reveal distinct protein expression patterns, offering a reference for IUGR research.
Area of Science:
- Proteomics
- Neonatal Medicine
- Biochemistry
Background:
- Intrauterine growth retardation (IUGR) affects fetal development, necessitating better diagnostic and prognostic tools.
- Understanding proteomic alterations in IUGR newborns is crucial for identifying biomarkers and improving clinical outcomes.
- Gestational age significantly influences infant physiology and protein expression profiles.
Purpose of the Study:
- To compare the serum proteome of newborns with IUGR versus appropriate for gestational age (AGA) infants.
- To identify significant protein expression differences related to IUGR across various gestational ages (Very Preterm, Moderate Preterm, Term).
- To provide a reference dataset for future research on IUGR during the first month of life.
Main Methods:
- Proteomic analysis using two-dimensional electrophoresis (2DE) and mass spectrometry (MS-TOF/TOF).
- Serum samples collected from 43 IUGR and 45 AGA newborns at three time points from birth to 1 month.
- Depletion of high-abundance proteins followed by analysis of low-abundance proteins to identify expression differences.
Main Results:
- Significant differences in serum protein expression were observed between IUGR and AGA newborns.
- Protein expression patterns varied based on gestational age categories (Very Preterm, Moderate Preterm, Term).
- The study optimized conditions for 2-DE separation and analysis of neonatal serum proteomes.
Conclusions:
- The proteomic dataset provides valuable insights into the molecular changes associated with IUGR in newborns.
- This data can serve as a reference for studies investigating IUGR and its impact on infant health.
- Further research can leverage these findings to develop targeted interventions and improve the management of IUGR.
Abstract:
The data are related to the proteomic analysis of 43 newborns with intrauterine growth retardation (IUGR) and 45 newborns with appropriate weight for gestational age (AGA) carried out by separation via 2DE and analyzed by MS-TOF/TOF. All newborns were separated into three gestational age groups, "Very Preterm" 29-32 weeks, "Moderate Preterm" 33-36 weeks, and, "Term" ≥37weeks. From each newborn, blood was drawn three times from birth to 1 month life. High-abundant serum proteins were depleted, and the minority ones were separated by 2DE and analyzed for significant expression differences. The data reflect analytic and clinic variables analyzed globally and categorized by gestational age in relation to IUGR and the optimization of conditions for 2-DE separation. The data from this study are related to the research article entitled "Alterations of Protein Expression in Serum of Infants with Intrauterine Growth Restriction and Different Gestational Ages" (M.D. Ruis-González, M.D. Cañete, J.L. Gómez-Chaparro, N. Abril, R. Cañete, J. López-Barea, 2015) [1]. The present dataset of serum IUGR newborn proteome can be used as a reference for any study involving intrauterine growth restriction during the first month of life.
