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Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

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The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging

Jarmila Nahálková1

  • 1Department of Medical Biochemistry and Microbiology (IMBIM), BMC, Uppsala University, Box 582, 751 23, Uppsala, Sweden. jarmila.nahalkova@gmail.com.

Molecular and Cellular Biochemistry
|October 5, 2016
PubMed

Insights

This review details a protein network involved in aging and diseases. These proteins, including TPPII and SIRT6, show potential for developing new therapies against cancer and neurodegenerative conditions like Alzheimer's disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Aging and age-related diseases involve complex molecular mechanisms.
  • Protein-protein interactions play a crucial role in cellular functions and disease pathogenesis.
  • Identifying key proteins in these networks can reveal therapeutic targets.

Purpose of the Study:

  • To review the known protein-interaction network relevant to aging and age-related diseases.
  • To highlight proteins with potential as therapeutic targets for cancer and aging-related conditions.
  • To explore the dual roles of specific proteins in tumorigenesis and neurodegeneration.

Main Methods:

  • Literature review of protein-interaction networks.
  • Analysis of protein functions in aging, cancer, and neurodegenerative disease models.
  • Examination of protein involvement in metabolic pathways and cellular damage.

Main Results:

  • Identified key interacting proteins: TPPII, p53, MYBBP1A, CDK2, SIRT7, SIRT6, and CD147.
  • TPPII and SIRT6 influence glucose metabolism and malignant growth; SIRT6 shows neuroprotective effects against DNA damage.
  • CD147 and TPPII exhibit dual roles in tumorigenesis and Alzheimer's disease pathology through mechanisms like Aβ peptide degradation.

Conclusions:

  • The identified protein-interaction network is critical for understanding tumorigenesis, aging, and neurodegeneration.
  • Proteins like TPPII, SIRT6, and CD147 are promising candidates for developing novel therapeutics.
  • Further research into these interactions can lead to advancements in treating age-related diseases and cancer.
Keywords:
CD147MYBBP1AP53SIRT6SIRT7TPPII

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