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CAPD with an amino acid dialysis solution: a long-term, cross-over study
M Bruno1, C Bagnis, M Marangella
1Section of Nephrology, Mauriziano Umberto I Hospital, Turin, Italy.
Kidney International
|May 1, 1989
Summary
Amino acid dialysis solutions improve nutritional status in continuous ambulatory peritoneal dialysis (CAPD) patients by enhancing nitrogen balance and improving plasma amino acid profiles. They are safe osmotic agents but require monitoring for weight gain and acidosis.
Area of Science:
- Nephrology
- Nutritional Science
- Biochemistry
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) patients often experience nutritional and metabolic derangements.
- Standard dialysis solutions may not adequately address these complications.
Purpose of the Study:
- To evaluate the safety and efficacy of a 1% amino acid dialysis solution in CAPD patients.
- To assess its impact on nutritional status, metabolic parameters, plasma amino acid profiles, and peritoneal membrane function.
Main Methods:
- Prospective cross-over study involving six CAPD patients.
- Daily exchange with 2L of 1% amino acid solution for six months.
- Monthly assessments including medical exams, anthropometry, and dietary inquiry; biochemical tests.
- Quarterly evaluations of renal and peritoneal function, plasma/dialysate aminograms, and nitrogen balance.
Main Results:
- Positive nitrogen balance was achieved (+3.1 g/day from -1.3 g/day).
- Increased weight (fat and lean mass), decreased plasma cholesterol and triglycerides, and normalized amino acid profiles.
- Slight, significant decreases in plasma urea, pH, and bicarbonate; no change in plasma proteins.
- All parameters reverted to baseline after discontinuing amino acid administration.
Conclusions:
- Amino acids are safe and effective osmotic agents for CAPD, without toxic effects or peritoneal membrane impairment.
- They can improve nutritional status but necessitate management of potential weight gain and systemic acidosis.