Related Experiment Video

Updated: Mar 14, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

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The role of microRNAs in colorectal cancer

Ali Mohammadi1, Behzad Mansoori1, Behzad Baradaran2

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 5, 2016
PubMed

Insights

MicroRNAs are key regulators in colorectal cancer (CRC) development. This review highlights their potential as biomarkers for CRC diagnosis, prognosis, and novel therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) remains a leading global cancer.
  • MicroRNAs (miRNAs), small non-coding RNAs, regulate crucial cellular processes like differentiation and apoptosis.
  • Dysregulation of miRNAs is implicated in CRC carcinogenesis.

Purpose of the Study:

  • To review the multifaceted roles of microRNAs in colorectal cancer.
  • To explore the potential of miRNAs as diagnostic and prognostic biomarkers for CRC.
  • To discuss miRNA-based therapeutic strategies for CRC treatment.

Main Methods:

  • Literature review of studies investigating microRNA involvement in CRC.
  • Analysis of research on miRNA expression patterns in CRC patients.
  • Examination of emerging therapeutic approaches utilizing microRNAs.

Main Results:

  • Specific miRNA expression profiles can differentiate CRC from other colon diseases.
  • miRNAs show promise as predictive biomarkers for chemotherapy response.
  • Tumor suppressor miRNA replacement therapy offers a novel therapeutic avenue for CRC.

Conclusions:

  • MicroRNAs are integral to CRC development and progression.
  • miRNAs represent valuable biomarkers for CRC diagnosis and prognosis.
  • Targeting microRNAs holds significant potential for innovative CRC molecular therapies.
Keywords:
Colorectal cancerDiagnosisMicroRNAReplacement therapy

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