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[Morphohistochemical study of the large intestine in Hirschsprung's disease in children]
Insights
Hirschsprung's disease in children can be precisely identified by examining large intestine biopsy samples. A thick network of nerve fibers showing acetylcholinesterase (ACE) activity is a key diagnostic marker.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Histopathology
Abstract:
The morphohistochemical study of the biopsy specimens of the large intestine and operative material, obtained in 41 children with Hirschsprung's disease, in 34 children with combination of the Hirschsprung's disease and dolichosigmoid, and in 25--with dolichosigmoid, was carried out. It is shown, that the presence of a thick network of neural fibers with positive response to acetylcholinesterase (ACE) in the biopsy specimens of the large intestine and positive, or sharply positive response to ACE in the lamina propria and lamina muscularis of the mucosal layer is a precise morphologic marker of the Hirschsprung's disease.