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Related Concept Videos

Asepsis01:28

Asepsis

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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Urine Studies II: Urine Culture and Sensitivity Test01:26

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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Pneumonia III: Complications and Assessment01:30

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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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[Sepsis: new findings and developments. Update 2016].

Matthias Kochanek, Alexander Shimabukuro-Vornhagen, Michael von Bergwelt-Baildon

    Deutsche Medizinische Wochenschrift (1946)
    |October 5, 2016
    PubMed
    Summary

    Sepsis incidence and mortality remain high in Germany. New Sepsis-3 guidelines aim to improve early sepsis identification and treatment initiation for better patient outcomes.

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    Area of Science:

    • Critical Care Medicine
    • Infectious Diseases
    • Health Services Research

    Background:

    • Rising sepsis incidence and persistent high mortality rates in Germany necessitate updated clinical approaches.
    • Current treatment protocols, such as Early Goal-Directed Therapy (EGDT), require re-evaluation due to their age.
    • The Sepsis-3 definition offers a framework for more precise patient identification.

    Purpose of the Study:

    • To emphasize the critical need for rapid identification and management of sepsis.
    • To highlight the limitations of existing treatment algorithms like EGDT.
    • To advocate for the adoption of the Sepsis-3 definition for improved sepsis care.

    Main Methods:

    • Analysis of recent DRG (Diagnosis Related Groups) data to assess sepsis incidence.
    • Review of existing literature and clinical guidelines on sepsis management.
    • Comparison of Sepsis-3 criteria with previous definitions and treatment protocols.

    Main Results:

    • DRG data indicate an increasing trend in sepsis incidence in Germany.
    • Mortality rates associated with sepsis remain unacceptably high.
    • The Sepsis-3 definition provides a more refined approach to identifying septic patients.

    Conclusions:

    • Optimizing the identification and timely initiation of therapy are paramount for reducing sepsis-related mortality.
    • Rapid antibiotic administration and effective therapy management are crucial components of modern sepsis care.
    • The Sepsis-3 definition supports a more effective and evidence-based approach to managing sepsis patients.