Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.6K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.6K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

998
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
998
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.7K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.7K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

871
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
871
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upcoming Treatments in Celiac Disease: From Luminal Enzymes to Oral Immune Tolerance.

United European gastroenterology journal·2026
Same author

European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow-Up, and Complex Disease Courses.

United European gastroenterology journal·2026
Same author

Quality of Care and Burden in Patients with Celiac Disease: Results from the German Celiac Registry.

Digestion·2026
Same author

European Society for the Study of Coeliac Disease 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 1: Diagnostic Approach.

United European gastroenterology journal·2025
Same author

Reply.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2024
Same author

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4<sup>+</sup> T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease.

Gastroenterology·2024
Same journal

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

["Not everything that looks like a tumor..." - Pulmonary tularemia with hilar lymphadenopathy].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Emergency management of sickle cell disease].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Hereditary dehydrated stomatocytosis (= hereditary xerocytosis) - Interesting hummingbird or clinically relevant diagnosis?]

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Diagnosis of Congenital Hemolytic Anemias in Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[46-year-old female patient with right upper abdominal pain].

Deutsche medizinische Wochenschrift (1946)·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

[Celiac disease].

Michael Schumann, Lydia Lebenheim

    Deutsche Medizinische Wochenschrift (1946)
    |October 5, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Celiac disease is an immune reaction to gluten peptides, influenced by genetics. Diagnosis requires a gluten-containing diet, and the primary treatment is a strict gluten-free diet, though new therapies are emerging.

    More Related Videos

    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
    06:46

    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

    Published on: July 5, 2022

    3.4K
    Chronic Salmonella Infection Induced Intestinal Fibrosis
    08:40

    Chronic Salmonella Infection Induced Intestinal Fibrosis

    Published on: September 22, 2019

    7.7K

    Related Experiment Videos

    Last Updated: Mar 14, 2026

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
    10:27

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

    Published on: December 15, 2011

    25.1K
    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
    06:46

    A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

    Published on: July 5, 2022

    3.4K
    Chronic Salmonella Infection Induced Intestinal Fibrosis
    08:40

    Chronic Salmonella Infection Induced Intestinal Fibrosis

    Published on: September 22, 2019

    7.7K

    Area of Science:

    • Immunology
    • Genetics
    • Gastroenterology

    Background:

    • Celiac disease results from a T-cell immune response to gluten peptides.
    • It is a complex genetic disorder with over 50 identified genes.
    • Genetic factors aid in identifying individuals with mild or subclinical celiac disease.

    Purpose of the Study:

    • To summarize the understanding of celiac disease pathogenesis, genetics, diagnostics, and treatment.
    • To highlight the importance of dietary gluten for accurate diagnosis.
    • To explore potential future therapeutic strategies beyond a gluten-free diet.

    Main Methods:

    • Review of current scientific literature on celiac disease.
    • Analysis of genetic studies, including whole genome association studies.
    • Discussion of diagnostic methods (serology, histology) and established treatment.

    Main Results:

    • Genetic predisposition plays a significant role in celiac disease development.
    • Accurate diagnosis relies on specific protocols, including gluten consumption.
    • A gluten-free diet remains the cornerstone of celiac disease management.

    Conclusions:

    • Understanding the genetic basis of celiac disease aids in early detection.
    • Adherence to diagnostic guidelines ensures reliable results.
    • Future research focuses on innovative treatments targeting gluten inactivation and immune modulation.