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Development of Antithrombotic Aptamers: From Recognizing Elements to Drugs
Elena Zavyalova1, Andrey Golovin, Galina Pavlova
1Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, Moscow, 119991 Russian Federation. zlenka2006@gmail.com.
Current Pharmaceutical Design
|October 6, 2016
Summary
Aptamers, a novel class of DNA/RNA molecules, show promise as antithrombotic drugs. Their specific binding and controllable action, with a potential antidote, offer advantages over current treatments for thrombosis.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Blood hemostasis relies on coagulation and platelet activation systems.
- Thrombosis-related events are frequent, necessitating effective antithrombotic strategies.
- Current antithrombotic inhibitors have limitations, highlighting the need for controllable agents.
Purpose of the Study:
- To explore aptamers as a novel class of antithrombotic agents.
- To review aptamers with potential antithrombotic activity.
- To assess the suitability of aptamers for developing controllable anticoagulants and antiplatelets.
Main Methods:
- Review of existing literature on aptamers and their antithrombotic properties.
- Analysis of aptamer characteristics, including affinity, specificity, and potential for antidote development.
- Examination of aptamers in preclinical and clinical trials for antithrombotic applications.
Main Results:
- Aptamers are DNA/RNA oligonucleotides with specific tertiary structures capable of high-affinity target binding.
- Aptamers offer potential for developing antithrombotic drugs with high specificity and low toxicity.
- A rational antidote can be designed for aptamer-based therapies, enabling controllable hemostasis restoration.
Conclusions:
- Aptamers represent a promising novel drug class for antithrombotic therapy.
- Their specific binding, controllable action, and potential for antidotes address limitations of current treatments.
- Several aptamers are under investigation, with some progressing to clinical trials.
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