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SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Tingting Yu1,2,3, Yong Zuo1,2, Rong Cai1,2

  • 1Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Journal of Molecular Cell Biology
|October 6, 2016
PubMed
Summary

SENP1 regulates macrophage inflammation by controlling the balance between STAT1 and STAT3 signaling pathways. This balance is crucial for M1 macrophage activation and effective resistance to Listeria monocytogenes infection.

Keywords:
IFN-γSENP1SUMOylationmacrophage

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