Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.1K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

999
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
999
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

1.9K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
1.9K
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

1.9K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
1.9K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

827
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
827

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipopolysaccharide induces epithelial-mesenchymal transition of alveolar epithelial cells cocultured with macrophages possibly via the JAK2/STAT3 signaling pathway.

Human & experimental toxicology·2019
Same author

Association between depression subtypes and response to repeated-dose intravenous ketamine.

Acta psychiatrica Scandinavica·2019
Same author

An excellent response to topical therapy of four congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome patients with an increased concentration of simvastatin ointment.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

The Subgingival Microbiome Relationship to Periodontal Disease in Older Women.

Journal of dental research·2019
Same author

[The efficacy and safety of surgical treatment after neoadjuvant chemotherapy for cT4N+ colon cancer].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2019
Same author

Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium.

Annals of oncology : official journal of the European Society for Medical Oncology·2019

Related Experiment Video

Updated: Mar 14, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Wuling Capsule for Major Depressive Disorder: A Meta-analysis of Randomised Controlled Trials.

W Zheng1, Y F Zhang2, H Q Zhong1

  • 1The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, PR China.

East Asian Archives of Psychiatry : Official Journal of the Hong Kong College of Psychiatrists = Dong Ya Jing Shen Ke Xue Zhi : Xianggang Jing Shen Ke Yi Xue Yuan Qi Kan
|October 6, 2016
PubMed
Summary
This summary is machine-generated.

Wuling capsule, a traditional Chinese medicine, may improve major depressive disorder symptoms when combined with antidepressants, showing fewer side effects than antidepressants alone. Further research is needed for confirmation.

Keywords:
Antidepressive agentsDepressive disorder, majorDrugs, Chinese herbal

More Related Videos

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

956
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

685

Related Experiment Videos

Last Updated: Mar 14, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K
Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

956
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

685

Area of Science:

  • Integrative Medicine
  • Psychiatry
  • Pharmacology

Background:

  • Wuling capsule, derived from Xylaria nigripes fungus, is a traditional Chinese medicine used for major depressive disorders.
  • Evidence on Wuling capsule's efficacy and safety, alone or combined with antidepressants, requires systematic evaluation.

Purpose of the Study:

  • To compare the efficacy and safety of Wuling capsule monotherapy versus Wuling capsule-antidepressant combination therapy for major depressive disorders.
  • To synthesize findings from randomized controlled trials (RCTs) to assess treatment outcomes.

Main Methods:

  • A meta-analysis of 12 RCTs involving 880 patients was conducted.
  • Data on symptomatic improvement, response, remission, and adverse events were extracted and analyzed.
  • Standard mean difference and risk ratios (RR) with 95% confidence intervals (CI) were calculated.

Main Results:

  • Wuling capsule-antidepressant combination therapy demonstrated superiority over antidepressant monotherapy in symptomatic improvement (SMD: -0.46, p=0.001), response rates (RR=1.23, p=0.03), and remission rates (RR=1.35, p=0.05).
  • No significant differences were found between Wuling capsule alone and antidepressant monotherapy for these outcomes.
  • Wuling capsule was associated with a lower incidence of adverse drug reactions compared to antidepressant monotherapy.

Conclusions:

  • Adjunctive Wuling capsule may enhance antidepressant efficacy in treating major depressive disorders.
  • Wuling capsule treatment appears to have a favorable safety profile with fewer adverse drug reactions.
  • Larger, high-quality RCTs are recommended to further validate these findings.