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Updated: Mar 14, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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OAHG: an integrated resource for annotating human genes with multi-level ontologies.

Liang Cheng1, Jie Sun1, Wanying Xu1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, P. R. China.

Scientific Reports
|October 6, 2016
PubMed
Summary

The OAHG resource provides a unified functional annotation for human protein-coding genes (PCGs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). This integrated database uses multiple ontologies to enhance understanding of gene function and relationships.

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Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Existing databases individually annotate protein-coding genes (PCGs), miRNAs, and lncRNAs.
  • Standardized terminologies like Gene Ontology (GO) aid analysis but a unified resource is lacking.
  • Functional annotation of these three key human gene types remains fragmented.

Purpose of the Study:

  • To develop OAHG, a comprehensive integrated resource for functional annotation of human PCGs, miRNAs, and lncRNAs.
  • To leverage multi-level ontologies including Gene Ontology (GO), Disease Ontology (DO), and Human Phenotype Ontology (HPO).
  • To consolidate information from multiple gene functional and interaction databases.

Main Methods:

  • Integration of data from six gene functional databases and two interaction databases.
  • Utilizing GO, DO, and HPO ontologies for multi-level functional annotation.
  • Development of the OAHG database (release 1.0, June 2016) with over 1.4 million entries.

Main Results:

  • OAHG version 1.0 contains 1,434,694 entries for 16,929 PCGs, 637 miRNAs, and 193 lncRNAs.
  • The resource incorporates 24,894 ontology terms from GO, DO, and HPO.
  • Performance evaluation demonstrated consistency with existing gene interactions and ontology structures.

Conclusions:

  • OAHG establishes a unified resource for human gene functional annotation.
  • The integrated approach enhances the study of PCGs, miRNAs, and lncRNAs.
  • OAHG provides a valuable tool for biological research and functional genomics.