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Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid

Huairong Zhang1, Bo Gao2, Bingyin Shi1

  • 1Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Disease Markers
|October 6, 2016
PubMed

Insights

This study identifies key protein kinases like SRC, MAPK, and EGFR involved in papillary thyroid carcinoma (PTC) progression. Targeting these kinases with combined inhibitors may offer a novel therapeutic strategy for PTC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Papillary thyroid carcinoma (PTC) pathophysiology involves complex molecular mechanisms.
  • Identifying key protein kinases is crucial for developing targeted therapies.

Purpose of the Study:

  • To identify protein kinases implicated in PTC.
  • To explore potential therapeutic targets for kinase inhibitors.
  • To elucidate molecular mechanisms underlying PTC.

Main Methods:

  • Analysis of gene expression profile (GSE27155) to identify differentially expressed genes.
  • Mapping identified genes to a human protein kinases database.
  • Systematic literature search, Gene Ontology (GO), and KEGG pathway analysis to correlate kinases with PTC.

Main Results:

  • The "mitogen-activated protein kinases pathway" was highly enriched, along with neurotrophin signaling, focal adhesion, and GnRH signaling pathways.
  • SRC, MAPK, PDGFRa, ErbB, and EGFR were significantly regulated.
  • Several kinases were identified as potential therapeutic targets for PTC treatment.

Conclusions:

  • SRC, MAPK, and EGFR are the most significant differentially expressed kinases in PTC.
  • Targeting these kinases with combined inhibitors presents a promising therapeutic approach for PTC.

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