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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Mar 14, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
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Thermal ablation in cancer.

Yong Liu1, Cheng-Song Cao1, Yang Yu1

  • 1Department of Internal Medicine-Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.

Oncology Letters
|October 6, 2016
PubMed
Summary

Radiofrequency ablation (RFA) and cryoablation modulate the immune system, impacting cancer development. These therapies cause inflammation and tissue disruption, influencing the tumor microenvironment and leading to an immunogenic gene signature.

Keywords:
ablationcancercryoablationradiofrequency ablationtumor

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Area of Science:

  • Oncology
  • Immunology
  • Medical Physics

Background:

  • Radiofrequency ablation (RFA) and cryoablation are established therapies for various conditions.
  • These ablation techniques are increasingly recognized for their immunomodulatory capabilities.
  • Recent research explores their application within the tumor microenvironment and systemic circulation.

Purpose of the Study:

  • To review the current understanding of RFA and cryoablation in cancer treatment.
  • To elucidate the immunomodulatory effects of these ablation techniques.
  • To highlight their impact on the tumor microenvironment and immune response.

Main Methods:

  • Review of existing scientific literature on RFA and cryoablation in oncology.
  • Analysis of studies investigating the immune response to ablation therapies.
  • Examination of research on the effects of ablation on tumor microenvironment and gene expression.

Main Results:

  • Ablation techniques induce a significant local inflammatory response.
  • These procedures lead to tissue disruption and an immunogenic gene signature.
  • RFA and cryoablation demonstrate potential in modulating the immune system against cancer.

Conclusions:

  • RFA and cryoablation are effective in modulating the immune system in the context of cancer.
  • The inflammatory response and tissue disruption caused by ablation contribute to anti-cancer effects.
  • These techniques offer a promising approach for cancer therapy by influencing the tumor microenvironment and systemic immunity.