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An Intracranial Gliosis Mimicking Neoplasm: A Dilemma
Zhi-Hong Shao1, Guo-Liang Wang1, Xiang-Hua Yi2
1Department of Radiology, Tongji Hospital of Tongji University, School of Medicine, Shanghai, China.
Abstract:
Intracranial gliosis has no typical clinical signals or imaging characteristics. Therefore, it can be easily misdiagnosed as neoplasm. Hereby, we report a unique case of gliosis that grew outward from the surface of the brain. MRI depicted its signal and enhancement pattern similar to the cerebral gray matter. The diagnosis was confirmed by pathology and immunohistochemistry. Although it was difficult to reach a diagnosis, correlating its origin, growing pattern and MR features and knowing that gliosis can present this way may help in differentiating it from other diseases.
Insights
Intracranial gliosis can mimic brain tumors due to non-specific imaging. This unique case highlights outward brain surface growth, aiding differential diagnosis.
Area of Science:
- Neuropathology
- Neuroradiology
- Neuro-oncology
Background:
- Intracranial gliosis often lacks distinct clinical and imaging features.
- This ambiguity can lead to misdiagnosis, particularly with neoplasms.
- Differentiating gliosis from tumors is crucial for appropriate patient management.
Observation:
- A rare case of intracranial gliosis presenting with outward growth from the brain surface is described.
- Magnetic Resonance Imaging (MRI) revealed signal and enhancement patterns resembling cerebral gray matter.
- The unusual presentation posed diagnostic challenges.
Findings:
- Pathology and immunohistochemistry confirmed the diagnosis of gliosis.
- The outward growth pattern and specific MRI characteristics were key diagnostic elements.
- The case demonstrates an atypical presentation of intracranial gliosis.
Implications:
- Recognizing this unusual growth pattern and MRI signature can aid in differentiating gliosis from brain neoplasms.
- This case expands the understanding of gliosis's varied presentations.
- Improved diagnostic accuracy for intracranial gliosis can prevent unnecessary oncological treatments.
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