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Updated: Mar 14, 2026

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Published on: January 28, 2012
GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder
Chih-Ken Chen1, Chau-Shoun Lee2, Hsuan-Yu Chen3
1, MD, PhD, Chang Gung University School of Medicine, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan.
Background:
Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders.
Aims:
To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder.
Method:
Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215).
Results:
GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence.
Conclusions:
GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients.
Declaration Of Interest:
None.
Copyright And Usage:
© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
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