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Updated: Mar 14, 2026

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
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External Otitis: An Unusual Presentation in Neonates.

Peymaneh Alizadeh Taheri1, Shima Rostami1, Manelie Sadeghi1

  • 1Pediatrics Department, Tehran University of Medical Sciences, Tehran, Iran.

Case Reports in Infectious Diseases
|October 6, 2016
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Summary

Acute otitis externa (AOE), typically seen in children over 2, rarely affects newborns. This case details a 23-day-old infant with methicillin-sensitive Staphylococcus aureus AOE, successfully treated with cloxacillin.

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Area of Science:

  • Otolaryngology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Acute otitis externa (AOE) is a common ear infection primarily affecting children over two years old.
  • Neonatal infections require prompt diagnosis and management due to potential complications.

Purpose of the Study:

  • To report an unusual case of AOE caused by Staphylococcus aureus in a neonate.
  • To highlight the importance of considering AOE in neonates presenting with ear discharge and irritability.

Main Methods:

  • A case report of a 23-day-old female infant presenting with ear discharge and irritability.
  • Clinical examination, otoscopy, and laboratory culture of ear discharge.
  • Treatment with intravenous cloxacillin.

Main Results:

  • The ear discharge culture identified methicillin-sensitive Staphylococcus aureus.
  • The neonate showed significant clinical improvement within 48 hours of intravenous cloxacillin treatment.
  • No signs of otitis media were observed.

Conclusions:

  • This is the first reported case of methicillin-sensitive Staphylococcus aureus AOE in an immunocompetent newborn.
  • Staphylococcal infections can present atypically in neonates, necessitating a broad differential diagnosis.
  • Early recognition and appropriate antibiotic therapy are crucial for favorable outcomes in neonatal AOE.