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Sulfadiazine-Induced Obstructive Nephropathy Presenting with Upper Urinary Tract Extravasation
Maharan Kabha1, Snir Dekalo1, Sophie Barnes2
1Department of Urology, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv, Israel .
Journal of Endourology Case Reports
|October 6, 2016
Summary
Sulfadiazine can cause obstructive nephropathy, a rare side effect. This case highlights acute renal colic and urine extravasation in a patient treated for toxoplasmosis.
Area of Science:
- Nephrology
- Urology
- Pharmacology
Background:
- Sulfadiazine is a common antibiotic used for toxoplasmosis treatment.
- Obstructive nephropathy is an uncommon but serious side effect of sulfadiazine.
- Prompt recognition and management are crucial for patient outcomes.
Observation:
- A 31-year-old female developed acute renal colic and urine extravasation after starting sulfadiazine and pyrimethamine for ocular toxoplasmosis.
- Imaging revealed left hydronephrosis and urine leakage at the ureteropelvic junction.
- No urinary stones were identified as the cause.
Findings:
- This case represents the first reported instance of sulfadiazine-induced obstructive uropathy with urine extravasation.
- The patient's condition improved after the insertion of a temporary internal ureteral stent.
- Post-treatment imaging confirmed the resolution of urine extravasation.
Implications:
- Clinicians should consider sulfadiazine-induced obstructive uropathy in patients presenting with renal colic.
- Increased fluid intake is recommended for patients on sulfadiazine to mitigate risks.
- Early diagnosis and intervention, such as stenting, can effectively manage this rare complication.
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