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Online coupling techniques in ambient mass spectrometry.

Shuting Xu1, Yiding Zhang1, Linnan Xu1

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P. R. Chain. yu.bai@pku.edu.cn hwliu@pku.edu.cn.

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Summary

Ambient mass spectrometry (AMS) offers low matrix effects and high salt tolerance. This review details advances in online coupling techniques like gas chromatography and liquid chromatography with AMS for enhanced analysis.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • Ambient mass spectrometry (AMS) demonstrates low matrix effects and high salt tolerance.
  • This makes it suitable for direct coupling with various analytical techniques.

Purpose of the Study:

  • To summarize recent advancements in online coupling methods for ambient mass spectrometry.
  • To highlight different interface setups, performance metrics, and applications.

Main Methods:

  • Review of literature on online coupling of analytical techniques with AMS.
  • Focus on interfaces like desorption electrospray ionization (DESI) and direct analysis in real time (DART).
  • Analysis of coupled techniques including gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), surface plasmon resonance (SPR), and electrochemistry flow cells.

Main Results:

  • Successful online coupling of GC, LC, CE, SPR, and electrochemistry with AMS.
  • Demonstration of low matrix effects and high salt tolerance across various interfaces.
  • Detailed evaluation of limits of detection and matrix tolerance for different setups.

Conclusions:

  • Online coupling significantly enhances the capabilities of AMS.
  • These integrated techniques offer improved sensitivity, selectivity, and applicability in diverse analytical challenges.
  • Further development in interface design and application scope is expected.