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Effect of Potassium Comenate on CNS Functional Status in Rodents Exposed to Combined Hypoxia and Hypercapnia in
L V Shurygina1, E I Zlishcheva2, T V Androsova2
1A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia. balizfarm@mail.ru.
Abstract:
The effects of potassium comenate on functional state of CNS in mice and rats were studied in the open-field and hole-board tests under control conditions and after acute exposure to hypoxia-hypercapnia. The effects of potassium comenate on CNS were also studied in rodents subjected to propofol-induced sleep. Preliminary administration of 4 mg/kg potassium comenate for 3 days attenuated the posthypoxic changes in behavioral reactions (emotional anxiety/reactivity). The pronounced stress-protective effect of potassium comenate was observed both on days 1 and 14 after exposure to hypoxia-hypercapnia. Under normal conditions, potassium comenate moderated behavioral reactions and augmented somniferous effect of propofol. We hypothesized that the antihypoxic effect of potassium comenate is determined by its stress-protective and sedative potencies.
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