Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pathology of optic nerve aging.

L Giarelli1, G Grandi, M Delendi

  • 1University of Trieste, Department of Anatomic Pathology, Ospedale Maggiore, Trieste, Italy.

Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985)
|January 1, 1989
PubMed
Summary

Optic nerve pathology in the very elderly is often due to poor blood supply, affecting nerve fibers and the cribriform lamina. Lesion severity in the optic nerve may not correlate with ischemic damage seen elsewhere in the body.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving access to postpartum contraception - a review of global guidelines with ESCRH consensus recommendations for Europe.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2025
Same author

The difficult journey to treatment for women suffering from heavy menstrual bleeding: a multi-national survey.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2021
Same author

Contraception during Coronavirus-Covid 19 pandemia. Recommendations of the Board of the Italian Society of Contraception.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2020
Same author

The Complexity of Dreams: a Multiscale Entropy Study on Cardiovascular Variability Series.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

The 2015 World Health Organization Classification of lung tumors: new entities since the 2004 Classification.

Pathologica·2018
Same author

Sofosbuvir in combination with daclatasvir or simeprevir for 12 weeks in noncirrhotic subjects chronically infected with hepatitis C virus genotype 1: a randomized clinical trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018

Area of Science:

  • Ophthalmology
  • Neuropathology
  • Gerontology

Background:

  • The aging process can lead to various physiological changes, including those affecting the optic nerve.
  • Understanding age-related changes in the optic nerve is crucial for diagnosing and managing visual impairments in the elderly.

Purpose of the Study:

  • To investigate the specific pathological changes in the optic nerve of individuals aged 95-103 years.
  • To identify common lesions and their potential causes, particularly in relation to vascular supply.

Main Methods:

  • Autopsy-based investigation of optic nerve tissue from 50 elderly subjects (95-103 years old).
  • Histopathological examination to identify and quantify lesions such as fibrous thickness, nerve fiber slendering, and degenerative changes.

Related Experiment Videos

Main Results:

  • The most frequent findings were increased septal fibrous thickness and nerve fiber slendering.
  • Degenerative processes in the cribriform lamina, gliosis, demyelination, and corpora amylacea were also observed.
  • Complete arteriosclerotic disease was infrequent, and lesion severity did not consistently correlate with ischemic damage in other tissues.

Conclusions:

  • Optic nerve pathology in the advanced elderly appears primarily linked to inadequate blood supply.
  • The observed lesions suggest a specific vulnerability of the optic nerve to ischemic insults, even if not universally severe.