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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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Mesothelioma from asbestos exposures: Epidemiologic patterns and impact in the United States

Richard A Lemen1

  • 1a Department of Environmental Health , Emory University , Atlanta , Georgia , USA.

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
|October 6, 2016
PubMed

Insights

Mesothelioma, a rare cancer linked to asbestos exposure, affects thousands annually. This study examines the demographics and causes of asbestos-related mesothelioma, highlighting its preventable nature.

Area of Science:

  • Oncology
  • Environmental Health
  • Epidemiology

Background:

  • Mesothelioma is a rare cancer strongly linked to asbestos exposure.
  • The risk of mesothelioma increases with cumulative asbestos exposure.
  • Mesothelioma impacts the United States, causing 2,000-3,000 deaths yearly.

Purpose of the Study:

  • To examine the demographic and etiological characteristics of asbestos-related mesothelioma.
  • To understand the trends and contributing factors of mesothelioma incidence.
  • To investigate the underreporting of asbestos-associated mesothelioma.

Main Methods:

  • Review of demographic data related to mesothelioma cases.
  • Analysis of etiological factors, particularly asbestos exposure.
  • Examination of trends in mesothelioma incidence over time.

Main Results:

  • Mesothelioma is dose/intensity dependent on asbestos exposure.
  • Asbestos-associated mesothelioma is more common in men but rising in women.
  • Non-occupational asbestos exposure is a factor in women's mesothelioma cases.
  • Underreporting of asbestos-associated mesothelioma is suspected.

Conclusions:

  • Mesothelioma is a preventable cancer primarily caused by asbestos exposure.
  • Improved diagnostic coding (ICD-10) is expected to increase the reported correlation between mesothelioma and asbestos exposure.
  • Further research into non-occupational asbestos exposure is warranted.

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