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Ligand-Driven T Cell Receptor Selection in Celiac Disease

Nishant K Singh1, Brian M Baker1

  • 1Department of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.

Structure (London, England : 1993)
|October 6, 2016
PubMed

Recognition of antigens by T cell receptors (TCRs) underlies cellular immunity. By comparing how different TCRs recognize the key antigens associated with celiac disease, Petersen et al. (2016), in this issue of Structure, show how celiac antigen properties select immunologically distinct yet structurally and physically compatible TCRs, ultimately driving autoimmunity.

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