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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

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MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis

Jar-Yi Ho1, Ren-Jun Hsu1,2,3, Jui-Ming Liu4

  • 1Department of Pathology, and Graduate Institute of Pathology and Parasitology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Oncotarget
|October 6, 2016
PubMed

Insights

MicroRNA miR-382-5p promotes breast cancer by targeting the tumor suppressor RERG, which normally inhibits the Ras/ERK pathway. This finding reveals new diagnostic and prognostic markers for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Aberrant activation of the Ras/ERK pathway is crucial in breast cancer initiation and progression.
  • Ras-related and estrogen-regulated growth inhibitor (RERG) functions as a tumor suppressor, potentially regulating the Ras/ERK pathway.

Purpose of the Study:

  • To investigate the role of miRNAs in modulating the Ras/ERK pathway during breast cancer.
  • To elucidate the regulatory relationship between RERG and miR-382-5p in breast carcinogenesis.

Main Methods:

  • Investigated RERG's tumor suppressor function and its effect on Ras/ERK signaling.
  • Determined if miR-382-5p directly targets RERG.
  • Assessed the impact of miR-382-5p on breast cancer cell behavior in vitro and in vivo.
  • Correlated miR-382-5p and RERG expression with clinical breast cancer data.

Main Results:

  • RERG suppresses breast cancer cell proliferation and tumor formation by attenuating Ras/ERK signaling.
  • miR-382-5p directly targets and represses RERG, thereby promoting Ras/ERK pathway activation.
  • miR-382-5p enhances breast cancer cell viability, migration, invasion, and metastasis.
  • High miR-382-5p expression correlates with low RERG expression and predicts poorer breast cancer prognosis.

Conclusions:

  • miR-382-5p acts as an oncomiR by inhibiting the tumor suppressor RERG, promoting breast cancer progression.
  • The miR-382-5p/RERG axis represents a novel diagnostic and prognostic biomarker for breast cancer.
  • Targeting the miR-382-5p/RERG pathway may offer therapeutic strategies for breast cancer.
Keywords:
RERGRas/ERK pathwaybreast cancermiR-382-5p

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