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2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia
Hang Shao1,2, Wen-Li Mei3, Wen-Hua Dong4
1Horticultural and Garden College, Hainan University, Haikou 570228, Hainan, China. shaohang126@163.com.
Abstract:
Three new2-(2-phenylethyl)chromone derivatives (1-3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5-6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1-4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM.
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