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Published on: June 26, 2020
Zoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission Routes
Virginie Doceul1,2,3, Eugénie Bagdassarian4,5,6, Antonin Demange7,8,9
1French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Animal Health Laboratory, UMR (joint research unit) 1161 Virology, 94701 Maisons-Alfort, France. virginie.doceul@vet-alfort.fr.
Abstract:
During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role these possible animal reservoirs play in human infections. The aim of this review is to present the recent discoveries of animal HEVs and their classification within the Hepeviridae family, their zoonotic and species barrier crossing potential, and possible use as models to study hepatitis E pathogenesis. Lastly, this review describes the transmission pathways identified from animal sources.
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