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Updated: Mar 14, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Interleukin-6 -572G/C polymorphism and prostate cancer susceptibility.

W J Huang1,2, L J Wu2, Z C Min2

  • 1Department of Urology, the Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.

Genetics and Molecular Research : GMR
|October 6, 2016
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Summary

Interleukin-6 (IL6) overexpression in prostate cancer correlates with higher Gleason scores and increased PSA recurrence. The IL6 -572G/C polymorphism may influence prostate cancer risk, particularly in never-smokers.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer-associated inflammation promotes tumor growth.
  • Interleukin-6 (IL6) is a key inflammatory modulator.
  • The role of IL6 and its gene mutations in prostate cancer requires further clarification.

Purpose of the Study:

  • To investigate IL6 expression and its association with prostate cancer progression.
  • To examine the role of the IL6 -572G/C polymorphism (rs1800796) in prostate cancer susceptibility.
  • To assess the functional impact of the IL6 -572G/C polymorphism on gene expression.

Main Methods:

  • Utilized Oncomine database for IL6 expression analysis in prostate cancer.
  • Conducted a case-control study on the IL6 -572G/C polymorphism in a southern Han Chinese population.
  • Employed dual-luciferase reporter assays to evaluate promoter activity of IL6 alleles.

Main Results:

  • IL6 was overexpressed in prostate cancer tissues, correlating with higher Gleason scores.
  • Elevated IL6 expression linked to higher prostate-specific antigen (PSA) recurrence rates.
  • The -572G allele showed a borderline increased risk for prostate cancer (OR=1.31), particularly in never-smokers (OR=1.85), and exhibited higher transcriptional activity.

Conclusions:

  • IL6 overexpression and elevated PSA recurrence suggest IL6 involvement in prostate cancer progression.
  • The IL6 -572G/C polymorphism may influence prostate cancer susceptibility.
  • The -572G allele's increased activity indicates a potential mechanism for IL6's role in prostate cancer development.