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The Mind Bending Quest for Cognitive Enhancers.

E Arce1, M D Ehlers2

  • 1Neuroscience Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA.

Clinical Pharmacology and Therapeutics
|October 6, 2016
PubMed
Summary

Cognitive functioning is vital for daily life. New research in neurobiology and neuroscience offers hope for developing drugs to improve cognition in neuropsychiatric disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Science

Background:

  • Cognitive functioning is crucial for everyday activities.
  • Brain injuries can impair cognitive abilities, leading to significant medical and functional deficits.
  • Neuropsychiatric diseases often involve cognitive impairments.

Purpose of the Study:

  • To explore the potential for developing novel pharmacological agents for cognitive enhancement.
  • To leverage advances in neurobiology and circuit neuroscience for therapeutic development.
  • To address the unmet need for treatments improving cognitive function in neuropsychiatric disorders.

Main Methods:

  • Review of recent advances in neurobiology.
  • Analysis of circuit neuroscience findings.

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  • Evaluation of clinical assessment technologies.

    • Main Results:

    • Convergence of neurobiology, circuit neuroscience, and clinical assessment technologies.
    • Identification of promising avenues for pharmacological intervention.
    • Potential for developing agents to enhance cognitive function.

    Conclusions:

    • Advances in neuroscience and technology create opportunities for cognitive enhancement therapies.
    • Pharmacological development holds promise for treating cognitive deficits in neuropsychiatric conditions.
    • Future research can build upon these converging fields to improve patient outcomes.