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In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

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The soluble mannose receptor is released from the liver in cirrhotic patients, but is not associated with bacterial

Tea L Laursen1, Sidsel Rødgaard-Hansen2, Holger J Møller2

  • 1Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Liver International : Official Journal of the International Association for the Study of the Liver
|October 6, 2016
PubMed
Abstract

Insights

Soluble mannose receptor levels are elevated in the hepatic vein of cirrhosis patients, correlating with portal pressure and bleeding complications. This marker indicates cirrhosis complications but not bacterial translocation.

Area of Science:

  • Hepatology
  • Immunology
  • Gastroenterology

Background:

  • Intestinal bacterial translocation activates liver macrophages in cirrhosis.
  • Macrophages are key in liver inflammation and cirrhosis pathogenesis.
  • Soluble mannose receptor may indicate macrophage activation.

Purpose of the Study:

  • To investigate soluble mannose receptor release from hepatic macrophages in cirrhosis.
  • To determine associations between soluble mannose receptor, bacterial DNA, portal pressure, and complications.

Main Methods:

  • Investigated 28 cirrhotic patients undergoing TIPS insertion.
  • Analyzed portal and hepatic vein plasma for bacterial DNA and soluble mannose receptor using qPCR and ELISA.

Main Results:

  • Soluble mannose receptor levels were higher in the hepatic vein than the portal vein.
  • Levels correlated with portal pressure and Child-Pugh score.
  • Higher levels were observed in patients with acute variceal bleeding.

Conclusions:

  • Hepatic soluble mannose receptor is excreted, with higher levels in the hepatic vein.
  • Soluble mannose receptor levels correlate with portal pressure and acute variceal bleeding.
  • It serves as a marker for cirrhosis complications, not bacterial translocation.
Keywords:
bacterial DNAbacterial translocationcirrhosissoluble mannose receptortransjugular intrahepatic portosystemic shunt

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