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Updated: Mar 14, 2026

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Prophylactic clipping and post-polypectomy bleeding: a meta-analysis and systematic review.

Christine Boumitri1, Fazia A Mir1, Imran Ashraf1

  • 1Department of Medicine, University of Missouri, Columbia (Christine Boumitri, Fazia A. Mir, Imran Ashraf, Michelle L. Matteson-Kome, Matthew L. Bechtold), USA.

Annals of Gastroenterology
|October 7, 2016
PubMed
Summary

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Prophylactic clip placement after colon polypectomy does not significantly prevent bleeding for all polyps. Routine use is not recommended, though large polyps may benefit from this intervention.

Area of Science:

  • Gastroenterology
  • Endoscopic Procedures
  • Colorectal Cancer Screening

Background:

  • Post-polypectomy bleeding is a frequent complication of colonoscopy.
  • Prophylactic clip placement is a common practice to mitigate this risk, but its efficacy is debated.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the effectiveness of prophylactic clip placement in preventing post-polypectomy bleeding.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (Embase, Scopus, PubMed, etc.) up to April 2016.
  • A random-effects meta-analysis using odds ratio (OR) was performed to compare bleeding rates with and without prophylactic clipping.

Main Results:

  • Twelve studies met inclusion criteria from 530 initial articles.
Keywords:
Prophylacticbleedingclippolypectomy

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  • No statistically significant difference in post-polypectomy bleeding was observed between prophylactic clipping and no clipping across all analyzed studies, peer-reviewed studies, and randomized controlled trials.

    • Conclusions:

    • Routine prophylactic clipping for all polypectomies is not supported by current evidence for preventing post-polypectomy bleeding.
    • The benefit of prophylactic clipping for large polyps (>2 cm) remains uncertain, warranting further investigation.