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Familial Mediterranean fever: An updated review

İsmail Sarı1, Merih Birlik1, Timuçin Kasifoğlu2

  • 1Department of Internal Medicine, Division of Rheumatology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.

European Journal of Rheumatology
|October 7, 2016
PubMed

Insights

Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disease causing fever and inflammation. Early treatment is crucial to prevent severe complications like amyloidosis and improve quality of life.

Area of Science:

  • Genetics and Immunology
  • Autoinflammatory Diseases

Background:

  • Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disorder.
  • Characterized by recurrent episodes of fever and serosal inflammation.
  • Primarily impacts Jewish, Armenian, Turkish, and Arab populations, significantly reducing quality of life.

Approach:

  • This review summarizes current information on Familial Mediterranean Fever.
  • Focuses on the disease's characteristics, affected populations, and clinical impact.

Key Points:

  • FMF attacks and subclinical inflammation decrease patient quality of life.
  • Inadequate treatment increases the risk of amyloidosis, a major cause of mortality.
  • Understanding FMF is critical for timely diagnosis and management.

Conclusions:

  • Familial Mediterranean Fever requires prompt recognition and management.
  • Preventing complications like amyloidosis is a key treatment goal.
  • Further research and awareness are essential for affected populations.
Keywords:
Familial Mediterranean feveraetiologyamyloidosisreviewtreatment

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