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Relationship between endothelial dysfunction and microalbuminuria in familial Mediterranean fever
Hakan Güneş1, Tarık Kıvrak1, Mustafa Tatlısu1
1Clinic of Cardiology, Sivas Numune Hospital, Sivas, Turkey.
Objective:
The aim of our study is to investigate the relationship between microalbuminuria and flow-mediated dilatation in familial Mediterranean fever (FMF) patients.
Material And Methods:
In our study, there were two groups consisting of 54 patients who were out of the attack period (43 of whom had no microalbuminuria and 11 of whom had microalbuminuria) and 40 healthy controls (M/F: 12/28).
Results:
There was no statistically difference between patient and control groups'age (25.06±8.07, 22.89±6.00 years, respectively). Flow-mediated dilatation (FMD) percentages were significantly different between the three groups (p=0.01). It was observed that there was a correlation between microalbuminuria and FMD percentage.
Conclusion:
Endothelial dysfunction and renal damage occurred as a result of low-grade chronic inflammation. Microalbuminuria, which is the indicator of renal damage and endothelial dysfunction, and FMD show that endothelial functions can be used in the following of early detection of renal damage and endothelial functions in FMF patients.
Insights
Familial Mediterranean Fever (FMF) patients show a correlation between microalbuminuria and flow-mediated dilatation (FMD), indicating potential early markers for renal damage and endothelial dysfunction.
Area of Science:
- Rheumatology
- Nephrology
- Cardiology
Background:
- Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disease characterized by recurrent inflammatory attacks.
- Chronic low-grade inflammation in FMF can lead to systemic complications, including endothelial dysfunction and renal damage.
- Microalbuminuria serves as an early indicator of renal damage and is associated with cardiovascular risk.
Purpose of the Study:
- To investigate the relationship between microalbuminuria and flow-mediated dilatation (FMD) in patients with Familial Mediterranean Fever (FMF).
- To assess endothelial function and identify potential early markers of renal damage in FMF patients.
Main Methods:
- A study was conducted involving 54 FMF patients (out of attack period) and 40 healthy controls.
- FMF patients were categorized based on the presence (11 patients) or absence (43 patients) of microalbuminuria.
- Flow-mediated dilatation (FMD) was measured and compared across patient subgroups and controls.
Main Results:
- No significant age difference was observed between FMF patients and controls.
- Flow-mediated dilatation (FMD) percentages showed a statistically significant difference among the three groups (p=0.01).
- A significant correlation was found between the presence of microalbuminuria and reduced FMD percentages in FMF patients.
Conclusions:
- Endothelial dysfunction and renal damage are consequences of chronic inflammation in FMF.
- Microalbuminuria and FMD are valuable indicators of endothelial dysfunction and early renal damage in FMF patients.
- Monitoring FMD and microalbuminuria may aid in the early detection and management of subclinical organ damage in FMF.
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