Vitamin C Supplementation, APOE4 Genotype and Cognitive Functioning in a Rural-Dwelling Cohort
K Chaudhari1, N Sumien, L Johnson
1Sid E. O'Bryant, Ph.D., University of North Texas, Health Sciences Center, Department of Internal Medicine, 3500 Camp Bowie Blvd, Fort Worth, Texas, 76107, USA. Phone: (817)735-2961.
The Journal of Nutrition, Health & Aging
|October 7, 2016
Summary
Vitamin C supplementation benefits cognition, particularly in non-carriers of the Apolipoprotein E4 (APOE4) genotype. The positive association between vitamin C and cognitive function was not observed in APOE4 carriers.
Area of Science:
- Neuroscience
- Genetics
- Nutritional Science
Background:
- Apolipoprotein E4 (APOE4) genotype is linked to cognitive function.
- Vitamin C may improve cognition in elders, but findings are mixed.
- The influence of APOE4 on vitamin C's cognitive effects is unclear.
Purpose of the Study:
- To investigate if the association between vitamin C and cognition differs based on APOE4 genotype.
- To examine vitamin C's impact on cognitive function in a rural community cohort.
Main Methods:
- Analysis of 582 participants from a rural community cohort.
- Cognitive assessment using Repeatable Battery for the Assessment of Neuropsychological Status and The Executive Interview.
- APOE genotyping and statistical analysis (ANOVA, ANCOVA) stratified by APOE4 status.
Main Results:
- Vitamin C supplementation was linked to better immediate memory, visuospatial skills, language, and global cognition overall.
- Among APOE4 non-carriers, vitamin C showed significant positive associations with memory, visuospatial skills, language, attention, and global cognition.
- No significant association between vitamin C supplementation and cognitive function was found in APOE4 carriers.
Conclusions:
- Vitamin C supplementation is positively associated with cognition in a rural sample, with effects varying by APOE4 status.
- The findings suggest potential genotype-specific benefits of vitamin C for cognitive enhancement.
- Further research into genotype-specific cognitive enhancement strategies is warranted.
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