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Long noncoding RNA expression profile of infantile hemangioma identified by microarray analysis
Xiaowen Liu1, Renrong Lv1, Linfeng Zhang1
1Department of Burn & Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Summary
This study reveals long noncoding RNA (lncRNA) expression profiles in infantile hemangioma (IH), identifying key lncRNAs involved in angiogenesis and pathogenesis. MALAT1 knockdown demonstrated effects on cell apoptosis and cell cycle arrest in endothelial cells.
Area of Science:
- Vascular Biology
- Molecular Oncology
- Epigenetics
Background:
- Infantile hemangioma (IH) is a common childhood vascular tumor.
- Long noncoding RNAs (lncRNAs) are implicated in angiogenesis, but their role in IH is unknown.
Purpose of the Study:
- To investigate lncRNA expression profiles in IH.
- To explore the function and pathogenic role of lncRNAs in IH.
Main Methods:
- lncRNA microarrays were used to profile lncRNA expression in IH and normal tissues.
- Bioinformatic analyses, including gene ontology and co-expression networks, were performed.
- Quantitative PCR (QPCR) validated key findings, and MALAT1 knockdown was studied in HUVECs.
Main Results:
- Significant numbers of lncRNAs and messenger RNAs (mRNAs) were differentially expressed in IH.
- lncRNAs were found to target angiogenesis-related mRNAs.
- Key lncRNAs like MEG3, MEG8, FENDRR, and Linc00152 were associated with specific mRNAs.
- MALAT1 knockdown induced apoptosis and cell cycle arrest in HUVECs.
Conclusions:
- This study presents the first comprehensive lncRNA expression profile in infantile hemangioma.
- lncRNAs play a significant role in regulating angiogenesis and IH pathogenesis.
- Specific lncRNAs, such as MALAT1, may represent therapeutic targets for IH.
