Liver injury and multiple drug therapy

Analysis of the drugs used at the time of hepatic injury was carried out in a group of patients consecutively admitted to medical wards during a 10 years period (1965-1975). One drug was the possible cause in 26% of the patients and 74% of them were treated with multiple drug therapy. The most common drugs associated with liver damage have been sulphonamides, oral contraceptives, nitrofurantoin, methyldopa and phenothiazine derivatives.