"On Water" C(sp3)-H Functionalization/C-O/C-N Bonds Formations: Synthesis of Functionalized Oxazolidines and
Vanaparthi Satheesh1, Mani Sengoden1, Tharmalingam Punniyamurthy1
1Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
Abstract:
On water oxidative C(sp3)-H functionalization/C-O/C-N bonds formations using tetrabutylammonium iodide as the catalyst and tert-butyl hydroperoxide in water (T-Hydro) as the oxidant affords a potential route for the construction of functionalized oxazolidines and imidazolidines. The reaction is simple, regioselective, and effective at moderate temperature with broad substrate scope. In the case of optically active substrates, the oxidative cyclization can be accomplished with high optical purities.
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