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Related Experiment Video

Updated: Mar 14, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Familial Brain Periventricular Pseudocysts.

Shiri Shinar1, Gustavo Malinger, Zvi Leibovitz

  • 1Fetal Neurology Clinic, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.

Fetal Diagnosis and Therapy
|October 7, 2016
PubMed
Summary
This summary is machine-generated.

Recurrent periventricular pseudocysts (PVPC) in multiple pregnancies suggest a hereditary cause. These brain abnormalities, diagnosed via fetal MRI, typically show a favorable postnatal outcome in affected infants.

Keywords:
Fetal MRIFetal brainFetal ultrasoundGerminolysisPeriventricular pseudocystsPrenatal insults

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Area of Science:

  • Prenatal diagnosis
  • Fetal neuroimaging
  • Genetic counseling

Background:

  • Periventricular pseudocysts (PVPC) are rare findings during pregnancy.
  • This study investigates recurrent PVPC in consecutive pregnancies within families.

Purpose of the Study:

  • To report the rare occurrence of recurrent periventricular pseudocysts (PVPC) in consecutive pregnancies.
  • To analyze the postnatal outcomes of these cases and explore potential etiologies.

Main Methods:

  • Retrospective review of ultrasound databases from three major units.
  • Identification of patients with PVPC in at least two pregnancies.
  • Confirmation of diagnosis using fetal MRI and genetic analysis (amniocentesis).

Main Results:

  • Four families with recurrent PVPC (8 cases total) were identified.
  • Fetal MRI confirmed frontal or frontocaudal PVPC.
  • Normal karyotypes were observed in cases with amniocentesis.
  • Two pregnancies were terminated; six resulted in normal term deliveries with healthy infants.

Conclusions:

  • Recurrent PVPC across pregnancies suggests a potential hereditary basis.
  • Familial PVPC, particularly frontocaudal, appears to have a favorable prognosis, similar to isolated cases.