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Published on: February 5, 2018
Multivalent effect of glycopolypeptide based nanoparticles for galectin binding
Colin Bonduelle1, Hugo Oliveira2, Cony Gauche3
1Université de Bordeaux, LCPO, CNRS, UMR 5629, F-33600, Pessac, France. lecommandoux@enscbp.fr and CNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse, France. colin.bonduelle@lcc-toulouse.fr.
Abstract:
Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.
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