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Colin Bonduelle1, Hugo Oliveira2, Cony Gauche3

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Novel synthetic glycopolymers form nanoassemblies with potential therapeutic applications. Galactan-based nanoparticles showed enhanced binding to human galectins, suggesting a multivalent effect for treating galectin-related diseases.

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Area of Science:

  • Biomaterials Science
  • Glycobiology
  • Nanotechnology

Background:

  • Synthetic glycopolymers are key for creating bioinspired nanoassemblies.
  • Understanding glycan-protein interactions is crucial for therapeutic development.

Purpose of the Study:

  • To design novel amphiphilic glycopolypeptides incorporating lactose or galactan.
  • To prepare and characterize polymeric nanoassemblies with sizes under 50 nm.
  • To evaluate the bioactivity of different glycan surface units concerning human galectins.

Main Methods:

  • Synthesis of amphiphilic glycopolypeptides with lactose or galactan.
  • Preparation of polymeric nanoassemblies.
  • Assessment of glycan relative binding affinities to human galectins 1 and 3.

Main Results:

  • Nanoassemblies with sizes below 50 nm were successfully prepared.
  • Polymeric nanoparticles displaying galactan exhibited a significant multivalent effect.
  • Binding activity of galactan nanoparticles was notably increased compared to free galactan.

Conclusions:

  • The designed synthetic glycopolypeptides enable the creation of targeted nanoassemblies.
  • Galactan-functionalized nanoparticles show enhanced bioactivity due to a specific multivalent effect.
  • These findings highlight the therapeutic potential for galectin-related pathologies.