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Updated: Mar 14, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Redox tunable delivery systems: sweet block copolymer micelles via thiol-(bromo)maleimide conjugation
Antoine Petrelli1, Redouane Borsali1, Sébastien Fort1
1CERMAV, CNRS, Université Grenoble Alpes, 38000 Grenoble, France. sami.halila@cermav.cnrs.fr.
Abstract:
Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs.
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