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Retrotrapezoid nucleus in the rat.

R A Pearce1, R L Stornetta, P G Guyenet

  • 1Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville 22908.

Neuroscience Letters
|June 19, 1989
PubMed
Summary

Researchers confirmed the retrotrapezoid nucleus (RTN) in rats, a brainstem region potentially controlling breathing. This finding supports the RTN's role in respiratory regulation.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • The retrotrapezoid nucleus (RTN) is an anatomically identified cell group in the ventral medulla.
  • The RTN's potential role in breathing generation and control is of significant interest.

Purpose of the Study:

  • To confirm the existence of an RTN in rats analogous to the one found in cats.
  • To investigate the RTN's potential role in respiratory control.

Main Methods:

  • Retrograde transport of rhodamine microbeads from the ventral respiratory group (VRG) in rats.
  • Electrophysiological recordings from the RTN region.

Main Results:

  • Confirmed the existence of an analogous RTN cell group in rats.
  • Identified individual units within the RTN exhibiting respiratory-related activity.

Conclusions:

  • The findings support a role for the retrotrapezoid nucleus in the control of breathing.
  • This study provides evidence for the RTN's involvement in respiratory regulation in mammals.

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