Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

11.1K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
11.1K
Aging01:26

Aging

945
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
945
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.7K
Overview
85.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

787
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
787

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung allograft donors with excessive alcohol use have increased levels of human antimicrobial peptide LL-37.

Alcohol (Fayetteville, N.Y.)·2018
Same author

There is more than one interleukin 1.

Immunology today·2014
Same author

Evidence of oxidative injury during aging of the liver in a mouse model.

Journal of the American Aging Association·2013
Same author

A review of the potential applications and controversies of non-invasive testing for biomarkers of aspiration in the lung transplant population.

Clinical transplantation·2010
Same author

A spurious markedly increased serum estradiol level due to an IgA lambda.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2004
Same author

Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production.

Journal of leukocyte biology·2001
Same journal

Could we discuss the molecular signature of immune dysregulation?

Clinical and experimental immunology·2026
Same journal

The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management.

Clinical and experimental immunology·2026
Same journal

PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

Clinical and experimental immunology·2026
Same journal

Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

Clinical and experimental immunology·2026
Same journal

Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

Clinical and experimental immunology·2026
Same journal

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

3.3K

Innate immune responses in the ageing lung.

D M Boe1, L A Boule1, E J Kovacs1

  • 1Division of GI, Endocrine and Tumor Surgery, Department of Surgery, Mucosal Inflammation Program, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

Clinical and Experimental Immunology
|October 7, 2016
PubMed
Summary
This summary is machine-generated.

As populations age, older adults face increased infection risks due to immune system decline, known as inflamm-ageing. This review examines age-related immune defects contributing to higher rates of lung infections in the elderly.

Keywords:
aginginfectioninflammationlungmacrophagesneutrophilspneumonia

More Related Videos

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

8.1K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

3.3K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

8.1K

Area of Science:

  • Immunology
  • Gerontology
  • Infectious Diseases

Background:

  • Global demographics show a rapid increase in the population aged 60 and over, projected to exceed 2 billion by 2050.
  • Elderly individuals experience age-related immune dysfunction, termed 'inflamm-ageing,' increasing susceptibility to infections.
  • Lung infections, including bacterial pneumonias and viral infections, disproportionately affect older adults, leading to severe complications and higher mortality.

Purpose of the Study:

  • To review current research on bacterial and viral lung infections in the elderly.
  • To discuss age-related changes in innate immunity that predispose older adults to these infections.
  • To highlight the need for age-specific therapies for lung infections in this vulnerable population.

Main Methods:

  • Literature review of studies on aging, innate immunity, and lung infections.
  • Analysis of age-related changes in immune responses to microbial threats.
  • Synthesis of findings to identify immune defects contributing to increased infection rates.

Main Results:

  • Older adults exhibit a diminished capacity of the innate immune system to combat microbial pathogens.
  • Impaired immune response in the elderly leads to a higher incidence and severity of lung infections.
  • Age-related immune dysfunction is a key factor in worse outcomes, prolonged hospitalization, and complications like sepsis.

Conclusions:

  • Understanding innate immune defects in the elderly is crucial for developing targeted treatments.
  • Age-specific therapeutic strategies are needed to effectively manage lung infections in older populations.
  • Further research into inflamm-ageing can inform the design of interventions to improve health outcomes for aging individuals.